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Assessment of polycyclic aromatic hydrocarbon exposure, lung function, systemic inflammation, and genotoxicity in peripheral blood mononuclear cells from firefighters before and after a work shift.
- Source :
-
Environmental and molecular mutagenesis [Environ Mol Mutagen] 2018 Jul; Vol. 59 (6), pp. 539-548. Date of Electronic Publication: 2018 May 15. - Publication Year :
- 2018
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Abstract
- Firefighting is regarded as possibly carcinogenic, although there are few mechanistic studies on genotoxicity in humans. We investigated exposure to polycyclic aromatic hydrocarbons (PAH), lung function, systemic inflammation and genotoxicity in peripheral blood mononuclear cells (PBMC) of 22 professional firefighters before and after a 24-h work shift. Exposure was assessed by measurements of particulate matter (PM), PAH levels on skin, urinary 1-hydroxypyrene (1-OHP) and self-reported participation in fire extinguishing activities. PM measurements indicated that use of personal protective equipment (PPE) effectively prevented inhalation exposure, but exposure to PM occurred when the environment was perceived as safe and the self-contained breathing apparatuses were removed. The level of PAH on skin and urinary 1-OHP concentration were similar before and after the work shift, irrespective of self-reported participation in fire extinction activities. Post-shift, the subjects had reduced levels of oxidatively damaged DNA in PBMC, and increased plasma concentration of vascular cell adhesion molecule 1 (VCAM-1). The subjects reporting participation in fire extinction activities during the work shift had a slightly decreased lung function, increased plasma concentration of VCAM-1, and reduced levels of oxidatively damaged DNA in PBMC. Our results suggest that the firefighters were not exposed to PM while using PPE, but exposure occurred when PPE was not used. The work shift was not associated with increased levels of genotoxicity. Increased levels of VCAM-1 in plasma were observed. Environ. Mol. Mutagen. 59:539-548, 2018. © 2018 Wiley Periodicals, Inc.<br /> (Copyright © 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Air Pollutants, Occupational adverse effects
Air Pollutants, Occupational analysis
Comet Assay
DNA Damage drug effects
Firefighters
Humans
Inhalation Exposure adverse effects
Inhalation Exposure analysis
Leukocytes, Mononuclear metabolism
Lung physiology
Male
Middle Aged
Mutagens analysis
Occupational Exposure analysis
Oxidation-Reduction drug effects
Particulate Matter adverse effects
Particulate Matter analysis
Polycyclic Aromatic Hydrocarbons analysis
Inflammation etiology
Leukocytes, Mononuclear drug effects
Lung drug effects
Mutagens adverse effects
Occupational Exposure adverse effects
Polycyclic Aromatic Hydrocarbons adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1098-2280
- Volume :
- 59
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Environmental and molecular mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 29761929
- Full Text :
- https://doi.org/10.1002/em.22193