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Simultaneous determination of nine neonicotinoids in human urine using isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry.
- Source :
-
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2018 Sep; Vol. 240, pp. 647-652. Date of Electronic Publication: 2018 May 15. - Publication Year :
- 2018
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Abstract
- Neonicotinoids (neonics), a class of systemic insecticides, have been frequently detected in pollen, vegetables, and fruits. Recently, an increasing concern has been aroused for human exposure to neonics. However, biological monitoring for quantifying body burden of neonics has rarely been reported. In this study, we developed an isotope-dilution ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method to simultaneously quantify nine neonics, including acetamiprid (ACE), thiamethoxam (THIAM), imidacloprid (IMIP), clothianidin (CLO), flonicamid (FLO), thiacloprid (THIAC), dinotefuran (DIN), nitenpyram (NIT), and imidaclothiz (IMIT) in urine. The limits of quantification were 0.1 μg/L for ACE, FLO, DIN, NIT and IMIT, and 0.2 μg/L for THIAM, IMIP, CLO, and THIAC. The overall recoveries were 80.8-103%, 81.5-91.7% and 83.0-92.3% for QA/QC samples fortifying at 1, 25, and 100 μg/L levels, respectively. UPLC/MS/MS method was used to analyze urine samples obtained from 10 children in Hangzhou, China. The detection frequencies were 80% for ACE and IMIP, 70% for THIAM and CLO, 20% for DIN and IMIT and 10% for THIAC. FLO and NIT were not detected in those urine samples. The data provided here will be helpful for conducting biological monitoring of neonics exposure in the future.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Child
China
Guanidines urine
Humans
Indicator Dilution Techniques
Isotopes analysis
Niacinamide analogs & derivatives
Niacinamide urine
Nitro Compounds urine
Oxazines urine
Pyridines chemistry
Thiamethoxam
Thiazines urine
Thiazoles analysis
Thiazoles urine
Chromatography, High Pressure Liquid methods
Environmental Monitoring methods
Insecticides urine
Neonicotinoids urine
Tandem Mass Spectrometry methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6424
- Volume :
- 240
- Database :
- MEDLINE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 29772515
- Full Text :
- https://doi.org/10.1016/j.envpol.2018.04.144