Geographic range expansion of tetrodotoxin in amphibians - First record in Atelopus hoogmoedi from the Guiana Shield.

Authors :: Mebs D
Lorentz M
Yotsu-Yamashita M
Rößler DC
Ernst R
Lötters S
Source :: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2018 Aug; Vol. 150, pp. 175-179. Date of Electronic Publication: 2018 May 19.
Publication Year :: 2018
Abstract: For the first time, alcohol extracts of Atelopus hoogmoedi from the Guiana Shield in Suriname and Guyana were analyzed for the presence of tetrodotoxin (TTX) and of its analogues by high resolution hydrophilic interaction liquid chromatography/mass spectrometry. One specimen from Suriname was found to contain TTX and 4-epiTTX. Using a monoclonal antibody-based immunohistochemical staining technique, TTX was localized mainly in the granular glands and epithelium of the skin, but not in internal organs except liver showing weak TTX-positive reaction. In two specimens collected in Guyana, none of the toxins were detected.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Subjects :: Animal Distribution
Animals
South America
Bufonidae physiology
Tetrodotoxin metabolism

Language :: English
ISSN :: 1879-3150
Volume :: 150
Database :: MEDLINE
Journal :: Toxicon : official journal of the International Society on Toxinology
Publication Type :: Academic Journal
Accession number :: 29782950
Full Text :: https://doi.org/10.1016/j.toxicon.2018.05.011

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