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Fibrates in primary prevention of cardiovascular disease. Comments on the results of a systematic review of the Cochrane Collaboration.
- Source :
-
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis [Clin Investig Arterioscler] 2018 Jul - Aug; Vol. 30 (4), pp. 188-192. Date of Electronic Publication: 2018 May 19. - Publication Year :
- 2018
-
Abstract
- Fibrates are drugs that reduce triglycerides, elevate high-density lipoproteins, as well as decrease small, dense LDL particles. The results of a study have recently been published by the Cochrane Collaboration on fibrates efficacy and safety in the primary prevention of cardiovascular disease. This study includes a systematic review and a meta-analysis of 6 studies (16,135 patients) that evaluated the clinical benefits of fibrates compared to placebo use or other lipid-lowering drugs. This review showed evidence of a protective effect of the fibrates compared with placebo as regards a reduction 16% of a compound objective of death due to cardiovascular disease, non-fatal myocardial infarction, or non-fatal cerebrovascular accident (NNT: 112), and that reduce coronary morbidity and mortality by 21% (NNT: 125). In addition, fibrates could reduce previously established diabetic retinopathy. However, fibrates do not influence total mortality, or non-cardiovascular mortality. Its joint use with statins does not benefit patients without established cardiovascular disease, compared to the use of statins in monotherapy. Fibrates are safe, although they can elevate serum creatinine levels.<br /> (Copyright © 2018 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Cardiovascular Diseases etiology
Creatinine blood
Drug Therapy, Combination
Fibric Acids administration & dosage
Fibric Acids adverse effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hypolipidemic Agents administration & dosage
Hypolipidemic Agents adverse effects
Lipids blood
Primary Prevention
Cardiovascular Diseases prevention & control
Fibric Acids therapeutic use
Hypolipidemic Agents therapeutic use
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1578-1879
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 29789212
- Full Text :
- https://doi.org/10.1016/j.arteri.2018.04.002