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Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2018 Sep; Vol. 65 (9), pp. e27228. Date of Electronic Publication: 2018 May 24. - Publication Year :
- 2018
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Abstract
- Background: Previous natural history studies have advanced the understanding of sickle cell disease (SCD), but generally have not included sufficient lifespan data or investigation of the role of genetics in clinical outcomes, and have often occurred before the widespread use of disease-modifying therapies, such as hydroxyurea and chronic erythrocyte transfusions. To further advance knowledge of SCD, St. Jude Children's Research Hospital established the Sickle Cell Clinical Research and Intervention Program (SCCRIP), to conduct research in a clinically evaluated cohort of individuals with SCD across their lifetime.<br />Procedures: Initiated in 2014, the SCCRIP study prospectively recruits patients diagnosed with SCD and includes retrospective and longitudinal collection of clinical, neurocognitive, geospatial, psychosocial, and health outcomes data. Biological samples are banked for future genomics and proteomics studies. The organizational structure of SCCRIP is based upon organ/system-specific working groups and is opened to the research community for partnerships.<br />Results: As of August 2017, 1,044 (92.3% of eligible) patients with SCD have enrolled in the study (860 children and 184 adults), with 11,915 person-years of observation. Population demographics included mean age at last visit of 11.3 years (range 0.7-30.1), 49.8% females, 57.7% treated with hydroxyurea, 8.5% treated with monthly transfusions, and 62.9% hemoglobin (Hb) SS or HbSB <superscript>0</superscript> -thalassemia, 25.7% HbSC, 8.4% HbsB <superscript>+</superscript> -Thalassemia, 1.7% HbS/HPFH, and 1.2% other.<br />Conclusions: The SCCRIP cohort will provide a rich resource for the conduct of high impact multidisciplinary research in SCD.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Anemia, Sickle Cell genetics
Anemia, Sickle Cell therapy
Biological Specimen Banks organization & administration
Blood Transfusion
Body Fluids
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
Genotype
Hemoglobinopathies genetics
Humans
Hydroxyurea therapeutic use
Infant
Informed Consent
Longevity
Male
Patient Selection
Prospective Studies
Research Design
Sampling Studies
United States epidemiology
Anemia, Sickle Cell mortality
Longitudinal Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 65
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 29797644
- Full Text :
- https://doi.org/10.1002/pbc.27228