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Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function in l-NAME treated rats.
- Source :
-
Food research international (Ottawa, Ont.) [Food Res Int] 2018 Jul; Vol. 109, pp. 358-367. Date of Electronic Publication: 2018 Apr 22. - Publication Year :
- 2018
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Abstract
- Tiger nut tubers have been reportedly used for the treatment of erectile dysfunction (ED) in folk medicine without scientific basis. Hence, this study evaluated the effect of tiger nut on erectile dysfunction by assessing biochemical parameters relevant to ED in male rats by nitric oxide synthase (NOS) inhibitor, Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME) treatment. Rats were divided into five groups (n = 10) each: Control group; l-NAME plus basal diet; l-NAME plus Sildenafil citrate; diet supplemented processed tiger nut (20%) plus l-NAME;diet supplemented raw tiger nut (20%) plus l-NAME. l-NAME pre-treatment (40 mg/kg/day) lasted for 14 days. Arginase, acetycholinesterase (AChE) and adenosine deaminase (ADA) activities as well as nitric oxide levels (NO) in serum, brain and penile tissue were measured. l-NAME increased the activity of arginase, AChE and ADA and reduced NO levels. However, dietary supplementation with tiger nut caused a reduction on the activities of the above enzymes and up regulated nitric oxide levels when compared to the control group. The effect of tiger nut supplemented diet may be said to prevent alterations of the activities of the enzymes relevant in erectile function. Quercetin was revealed to be the most active component of tiger nut tuber by HPLC finger printing.<br /> (Copyright © 2018. Published by Elsevier Ltd.)
- Subjects :
- Acetylcholinesterase blood
Adenosine Deaminase blood
Animals
Arginase blood
Brain drug effects
Brain metabolism
Disease Models, Animal
Erectile Dysfunction chemically induced
Erectile Dysfunction metabolism
Erectile Dysfunction physiopathology
GPI-Linked Proteins blood
Male
Membrane Proteins blood
Nitric Oxide blood
Penis metabolism
Penis physiopathology
Plant Extracts isolation & purification
Plant Tubers chemistry
Quercetin isolation & purification
Rats, Wistar
Animal Feed
Cyperus chemistry
Dietary Supplements
Erectile Dysfunction prevention & control
NG-Nitroarginine Methyl Ester
Penile Erection drug effects
Penis drug effects
Plant Extracts pharmacology
Quercetin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7145
- Volume :
- 109
- Database :
- MEDLINE
- Journal :
- Food research international (Ottawa, Ont.)
- Publication Type :
- Academic Journal
- Accession number :
- 29803461
- Full Text :
- https://doi.org/10.1016/j.foodres.2018.04.046