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Self-Assembled Magnetic Viruslike Particles for Encapsulation and Delivery of Deoxyribonucleic Acid.
- Source :
-
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2018 Jun 19; Vol. 34 (24), pp. 7171-7179. Date of Electronic Publication: 2018 Jun 08. - Publication Year :
- 2018
-
Abstract
- Developing nontoxic artificial carriers for stimuli-responsive capture, transport, and delivery of biomolecules is of immense scientific interest. Herein, for the first time, we synthesize a double-tailed cationic surfactant, (C <subscript>16</subscript> H <subscript>33</subscript> ) <subscript>2</subscript> (CH <subscript>3</subscript> ) <subscript>2</subscript> N <superscript>+</superscript> [FeCl <subscript>3</subscript> Br] <superscript>-</superscript> , which possesses magnetic properties [magnetic surfactants (Mag-Surfs)]. The time-dependent formation of virus-shaped hybrid mixed assemblies of polyoxometalates (POMs) {Mo <subscript>72</subscript> Fe <subscript>30</subscript> }/Mag-Surf with hollow-shell structures is followed. These structures serve well as robust high-surface-area shuttles, which can be manipulated with applied magnetic fields. By using cationic Mag-Surfs, the anionic POMs and DNA can be complexed in these ternary mixtures. These virus-shaped complexes act as nanoanchors and nanomotors, which can be utilized for binding, anchoring, and delivery of biomolecules, such as DNA. It is found that they have a good absorption capacity for DNA and myoglobin over 24 h, after application of a magnetic field. The realization of magnetic virus-shaped {Mo <subscript>72</subscript> Fe <subscript>30</subscript> }/Mag-Surf spheres may open possibilities for designing other functional nanoparticles, allowing effective control over the delivery/separation of biomolecules.
Details
- Language :
- English
- ISSN :
- 1520-5827
- Volume :
- 34
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Publication Type :
- Academic Journal
- Accession number :
- 29809016
- Full Text :
- https://doi.org/10.1021/acs.langmuir.8b01445