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The Role of CHI3L1 Expression in Angiogenesis in Invasive Ductal Breast Carcinoma.

Authors :
Rusak A
Jablonska K
Piotrowska A
Grzegrzolka J
Nowak A
Wojnar A
Dziegiel P
Source :
Anticancer research [Anticancer Res] 2018 Jun; Vol. 38 (6), pp. 3357-3366.
Publication Year :
2018

Abstract

Background/aim: An increased level of chitinase 3 like 1 protein (CHI3L1) expression is observed in patients with cancer and may have potential prognostic value. The aim of this study was to evaluate the role of CHI3L1 in angiogenesis in invasive ductal breast carcinoma (IDC) (n=110).<br />Materials and Methods: Immunohistochemistry was used to assess the expression of CHI3L1, CD31, CD34, vascular endothelial growth factor (VEGFA, VEGFC and VEGFD). Real-time polymerase chain reaction and western blot were used to determine the level of CHI3L1 mRNA and protein.<br />Results: Immunohistochemistry demonstrated positive correlation between CHI3L1 expression and angiogenesis markers: CD31 (r=0.34, p=0.0003), CD34 (r=0.24, p=0.012), VEGFD (r=0.24, p=0.013). Higher CHI3L1 expression in estrogen receptor-negative (p=0.041) and progesterone receptor-negative (p=0.014) cancer was observed. Higher CHI3L1 expression was reported in cancer tissues in comparison to non-malignant breast lesions.<br />Conclusion: These results suggest a potential role of CHI3L1 in angiogenesis in IDC and may suggest its involvement in cancer progression.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Details

Language :
English
ISSN :
1791-7530
Volume :
38
Issue :
6
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
29848684
Full Text :
https://doi.org/10.21873/anticanres.12602