Back to Search
Start Over
The Role of CHI3L1 Expression in Angiogenesis in Invasive Ductal Breast Carcinoma.
- Source :
-
Anticancer research [Anticancer Res] 2018 Jun; Vol. 38 (6), pp. 3357-3366. - Publication Year :
- 2018
-
Abstract
- Background/aim: An increased level of chitinase 3 like 1 protein (CHI3L1) expression is observed in patients with cancer and may have potential prognostic value. The aim of this study was to evaluate the role of CHI3L1 in angiogenesis in invasive ductal breast carcinoma (IDC) (n=110).<br />Materials and Methods: Immunohistochemistry was used to assess the expression of CHI3L1, CD31, CD34, vascular endothelial growth factor (VEGFA, VEGFC and VEGFD). Real-time polymerase chain reaction and western blot were used to determine the level of CHI3L1 mRNA and protein.<br />Results: Immunohistochemistry demonstrated positive correlation between CHI3L1 expression and angiogenesis markers: CD31 (r=0.34, p=0.0003), CD34 (r=0.24, p=0.012), VEGFD (r=0.24, p=0.013). Higher CHI3L1 expression in estrogen receptor-negative (p=0.041) and progesterone receptor-negative (p=0.014) cancer was observed. Higher CHI3L1 expression was reported in cancer tissues in comparison to non-malignant breast lesions.<br />Conclusion: These results suggest a potential role of CHI3L1 in angiogenesis in IDC and may suggest its involvement in cancer progression.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Antigens, CD34 metabolism
Breast Neoplasms genetics
Breast Neoplasms pathology
Carcinoma, Ductal, Breast genetics
Carcinoma, Ductal, Breast pathology
Chitinase-3-Like Protein 1 genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Middle Aged
Neovascularization, Pathologic genetics
Neovascularization, Pathologic pathology
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
Vascular Endothelial Growth Factor A metabolism
Vascular Endothelial Growth Factor C metabolism
Vascular Endothelial Growth Factor D metabolism
Breast Neoplasms metabolism
Carcinoma, Ductal, Breast metabolism
Chitinase-3-Like Protein 1 biosynthesis
Neovascularization, Pathologic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 38
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 29848684
- Full Text :
- https://doi.org/10.21873/anticanres.12602