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A minireview of E4BP4/NFIL3 in heart failure.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2018 Nov; Vol. 233 (11), pp. 8458-8466. Date of Electronic Publication: 2018 Jun 01. - Publication Year :
- 2018
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Abstract
- Heart failure (HF) remains a major cause of morbidity and mortality worldwide. The primary cause identified for HF is impaired left ventricular myocardial function, and clinical manifestations may lead to severe conditions like pulmonary congestion, splanchnic congestion, and peripheral edema. Development of new therapeutic strategies remains the need of the hour for controlling the problem of HF worldwide. Deeper insights into the molecular mechanisms involved in etiopathology of HF indicate the significant role of calcium signaling, autocrine signaling pathways, and insulin-like growth factor-1 signaling that regulates the physiologic functions of heart growth and development such as contraction, metabolism, hypertrophy, cytokine signaling, and apoptosis. In view of these facts, a transcription factor (TF) regulating the myriad of these signaling pathways may prove as a lead candidate for development of therapeutics. Adenovirus E4 promoter-binding protein (E4BP4), also known as nuclear-factor, interleukin 3 regulated (NFIL3), a type of basic leucine zipper TF, is known to regulate the signaling processes involved in the functioning of heart. The current review discusses about the expression, structure, and functional role of E4BP4 in signaling processes with emphasis on calcium signaling mechanisms, autocrine signaling, and insulin-like growth factor II receptor-mediated processes regulated by E4BP4 that may regulate the pathogenesis of HF. We propose that E4BP4, being the critical component for the regulation of the above signaling processes, may serve as a novel therapeutic target for HF, and scientific investigations are merited in this direction.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Apoptosis genetics
Autocrine Communication genetics
Calcium Signaling genetics
Gene Expression Regulation genetics
Heart Failure pathology
Humans
Insulin-Like Growth Factor I genetics
Promoter Regions, Genetic
Transcription Factors genetics
Basic-Leucine Zipper Transcription Factors genetics
DNA-Binding Proteins genetics
Heart Failure genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 233
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 29856483
- Full Text :
- https://doi.org/10.1002/jcp.26790