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Maternal age at delivery, lung function and asthma in offspring: a population-based survey.
- Source :
-
The European respiratory journal [Eur Respir J] 2018 Jun 07; Vol. 51 (6). Date of Electronic Publication: 2018 Jun 07 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry.Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p <subscript>trend</subscript> 0.025) than in males (p <subscript>trend</subscript> 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p <subscript>interaction</subscript> 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors.Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.<br />Competing Interests: Conflict of interest: None declared<br /> (Copyright ©ERS 2018.)
- Subjects :
- Adolescent
Adult
Female
Forced Expiratory Volume
Health Surveys
Humans
Internationality
Linear Models
Logistic Models
Male
Middle Aged
Pregnancy
Prenatal Exposure Delayed Effects
Sex Factors
Smoking physiopathology
Young Adult
Asthma epidemiology
Asthma physiopathology
Immunoglobulin E blood
Lung physiopathology
Maternal Age
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3003
- Volume :
- 51
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The European respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 29880541
- Full Text :
- https://doi.org/10.1183/13993003.01611-2016