Evaluation of the Rapid Polymyxin NP test for detection of colistin susceptibility in Enterobacteriaceae isolated from Thai patients.

Authors :: Yainoy S
Hiranphan M
Phuadraksa T
Eiamphungporn W
Tiengrim S
Thamlikitkul V
Source :: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2018 Oct; Vol. 92 (2), pp. 102-106. Date of Electronic Publication: 2018 May 16.
Publication Year :: 2018
Abstract: Development and evaluations of the Rapid Polymyxin NP test for detection of colistin resistance in Enterobacteriaceae have been recently reported. In this study, we evaluated the performance of the test using a larger number of Enterobacteriaceae, and a larger proportion of isolates with a colistin MIC close to the breakpoint. Out of 339 isolates, the Rapid Polymyxin NP test detected colistin resistance in 13 isolates of Escherichia coli, 213 isolates of Klebsiella pneumoniae, 9 isolates of Enterobacter aerogenes, and 10 isolates of the other Enterobacteriaceae species. Sensitivity and specificity of the test for detecting colistin resistance were 100% and 95.9%, respectively. Positive predictive value and negative predictive value were 98.3% and 100%, respectively.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

Subjects :: Carbapenems pharmacology
Escherichia coli drug effects
Humans
Klebsiella pneumoniae drug effects
Microbial Sensitivity Tests
Thailand
Anti-Bacterial Agents pharmacology
Colistin pharmacology
Drug Resistance, Bacterial
Enterobacteriaceae drug effects
Enterobacteriaceae Infections microbiology
Polymyxins pharmacology

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