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The Impact of Preoperative Enteral Nutrition Enriched with Eicosapentaenoic Acid on Postoperative Hypercytokinemia after Pancreatoduodenectomy: The Results of a Double-Blinded Randomized Controlled Trial.
- Source :
-
Digestive surgery [Dig Surg] 2019; Vol. 36 (4), pp. 348-356. Date of Electronic Publication: 2018 Jun 08. - Publication Year :
- 2019
-
Abstract
- Aims: To investigate whether preoperative enteral diets -enriched in eicosapentaenoic acid (EPA) supplements could reduce the incidence of hypercytokinemia after pancreatoduodenectomy (PD) in a double-blinded randomized -controlled trial.<br />Methods: Patients with resectable periampullary cancer were randomized into either the control group or the treatment group. Patients in the treatment group received oral supplementation (600 kcal/day) containing EPA for 7 days before surgery. Patients in the control group received isocaloric isonitrogenous standard nutrition (600 kcal/day) without EPA for 7 days before surgery. The primary endpoint was postoperative serum concentrations of interleukin-6 (IL-6). The secondary endpoints were the postoperative nutritional status and the incidence of postoperative infectious complications.<br />Results: Twenty-four patients were enrolled in the present study. After exclusion, 20 patients (control group, n = 9; treatment group, n = 11) were analyzed. There were no significant differences in the curves for the serum concentration of IL-6 (p = 0.68) or the incidence of infectious complications between the 2 groups (control group: 78%, treatment group: 55%, p = 0.37).<br />Conclusions: The results of a double-blinded randomized controlled trial indicated that preoperative immunonutrition had no marked impact on the rates of postoperative hypercytokinemia or infectious complications after PD.<br /> (© 2018 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Biomarkers, Tumor blood
Double-Blind Method
Female
Humans
Interleukin-6 blood
Male
Middle Aged
Postoperative Complications epidemiology
Postoperative Complications prevention & control
Surgical Wound Infection epidemiology
Surgical Wound Infection prevention & control
Cytokines blood
Eicosapentaenoic Acid administration & dosage
Enteral Nutrition
Pancreatic Neoplasms surgery
Pancreaticoduodenectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9883
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Digestive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 29886499
- Full Text :
- https://doi.org/10.1159/000490110