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Quantitative EEG reflects non-dopaminergic disease severity in Parkinson's disease.
- Source :
-
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2018 Aug; Vol. 129 (8), pp. 1748-1755. Date of Electronic Publication: 2018 May 29. - Publication Year :
- 2018
-
Abstract
- Objective: In Parkinson's Disease (PD), measures of non-dopaminergic systems involvement may reflect disease severity and therefore contribute to patient-selection for Deep Brain Stimulation (DBS). There is currently no determinant for non-dopaminergic disease severity. In this exploratory study, we investigated whether quantitative EEG reflects non-dopaminergic disease severity in PD.<br />Methods: Sixty-three consecutive PD patients screened for DBS were included (mean age 62.4 ± 7.2 years, 32% females). Relative spectral powers and the Phase-Lag-Index (PLI) reflecting functional connectivity were analysed on routine EEGs. Non-dopaminergic disease severity was quantified using the SENS-PD score and its subdomains; motor-severity was quantified using the MDS-UPDRS III.<br />Results: The SENS-PD composite score correlated with a spectral ratio ((δ + θ)/(α1 + α2 + β) powers) (global spectral ratio Pearson's r = 0.4, 95% Confidence Interval (95%CI) 0.1-0.6), and PLI in the α2 band (10-13 Hz) (r = -0.3, 95%CI -0.5 to -0.1). These correlations seem driven by the subdomains cognition and psychotic symptoms. MDS-UPDRS III was not significantly correlated with EEG parameters.<br />Conclusions: EEG slowing and reduced functional connectivity in the α2 band were associated with non-dopaminergic disease severity in PD.<br />Significance: The described EEG parameters may have complementary utility as determinants of non-dopaminergic involvement in PD.<br /> (Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Deep Brain Stimulation trends
Electroencephalography trends
Female
Humans
Male
Middle Aged
Parkinson Disease surgery
Subthalamic Nucleus surgery
Deep Brain Stimulation methods
Electroencephalography methods
Parkinson Disease diagnosis
Parkinson Disease physiopathology
Severity of Illness Index
Subthalamic Nucleus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8952
- Volume :
- 129
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 29887401
- Full Text :
- https://doi.org/10.1016/j.clinph.2018.04.752