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Long noncoding RNA AFAP1-AS1 facilitates tumor growth through enhancer of zeste homolog 2 in colorectal cancer.
- Source :
-
American journal of cancer research [Am J Cancer Res] 2018 May 01; Vol. 8 (5), pp. 892-902. Date of Electronic Publication: 2018 May 01 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Increasing evidences have shown that long noncoding RNAs (lncRNAs) play critical regulatory roles in cancer biology. However, the contributions of lncRNAs to colorectal cancer remain largely unknown. Here, we identify a lncRNA AFAP1-AS1 that facilitates colorectal cancer, where it is upregulated. AFAP1-AS1 expression was associated with colorectal cancer patient survival. AFAP1-AS1 knockdown inhibited cell proliferation, cell cycle, and tumorigenesis in an subcutaneous mouse xenograft model system. Further data demonstrated that AFAP1-AS1 was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Our findings indicate that AFAP1-AS1 is an oncogenic lncRNA that promotes tumor progression and may be a novel prognostic factor in colorectal cancer. Targeting AFAP1-AS1 might be a potential therapeutic strategy for colorectal cancer treatment.<br />Competing Interests: None.
Details
- Language :
- English
- ISSN :
- 2156-6976
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- American journal of cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 29888110