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An Empirical Dietary Inflammatory Pattern Score Is Associated with Circulating Inflammatory Biomarkers in a Multi-Ethnic Population of Postmenopausal Women in the United States.
- Source :
-
The Journal of nutrition [J Nutr] 2018 May 01; Vol. 148 (5), pp. 771-780. - Publication Year :
- 2018
-
Abstract
- Background: The empirical dietary inflammatory pattern (EDIP) score has been associated with concentrations of circulating inflammatory biomarkers in European Americans.<br />Objective: We used the EDIP score, a weighted sum of 18 food groups that characterizes dietary inflammatory potential based on circulating concentrations of inflammatory biomarkers, to test the hypothesis that a pro-inflammatory dietary pattern is associated with inflammatory biomarker concentrations in a US multi-ethnic population.<br />Methods: In this cross-sectional study, we calculated EDIP scores using baseline food frequency questionnaire data from 31,472 women, aged 50-79 y, in the Women's Health Initiative observational study and clinical trials. Circulating biomarkers outcomes at baseline were: C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, TNF receptor (TNFR) 1 and 2, and adiponectin. We used multivariable-adjusted linear regression analyses to estimate absolute concentrations and relative differences in biomarker concentrations, overall and in subgroups of race/ethnicity and BMI (body mass index) categories.<br />Results: Independent of energy intake, BMI, physical activity, and other potential confounding variables, higher EDIP scores were significantly associated with higher (lower for adiponectin) absolute concentrations of all 6 biomarkers. On the relative scale, the percentage of difference in the concentration of biomarkers, among women in the highest compared to the lowest EDIP quintile, was: CRP, +13% (P-trend < 0.0001); IL-6, +15% (P-trend < 0.0001); TNF-α, +7% (P-trend = 0.0007); TNFR1, +4% (P-trend = 0.0009); TNFR2, +5% (P-trend < 0.0001); and adiponectin, -13% (P-trend <0.0001). These associations differed by racial/ethnic groups and by BMI categories. Whereas the absolute biomarker concentrations were lower among European-American women and among normal-weight women, the associations with diet were stronger than among women of African-American or Hispanic/Latino origin and among overweight and obese women.<br />Conclusions: Findings demonstrate the successful replication of an empirical hypothesis-oriented a posteriori dietary pattern score in a multi-ethnic population of postmenopausal women, with subgroup differences by race/ethnicity and body weight. Future research needs to apply the score in non-US populations.<br /> (© 2018 American Society for Nutrition.)
- Subjects :
- Adiponectin blood
Aged
Biomarkers blood
C-Reactive Protein metabolism
Cross-Sectional Studies
Female
Humans
Inflammation blood
Interleukin-6 blood
Middle Aged
Multivariate Analysis
Receptors, Tumor Necrosis Factor, Type I blood
Receptors, Tumor Necrosis Factor, Type II blood
Tumor Necrosis Factor-alpha blood
United States
Diet adverse effects
Ethnicity
Inflammation etiology
Inflammation Mediators blood
Postmenopause blood
Subjects
Details
- Language :
- English
- ISSN :
- 1541-6100
- Volume :
- 148
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 29897561
- Full Text :
- https://doi.org/10.1093/jn/nxy031