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Potential Immunological Links Between Psoriasis and Cardiovascular Disease.
- Source :
-
Frontiers in immunology [Front Immunol] 2018 Jun 01; Vol. 9, pp. 1234. Date of Electronic Publication: 2018 Jun 01 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Preclinical and clinical research provide strong evidence that chronic, systemic inflammation plays a key role in development and progression of atherosclerosis. Indeed, chronic inflammatory diseases, such as psoriasis, are associated with accelerated atherosclerosis and increased risk of cardiovascular events. Contemporary research has demonstrated plausible mechanistic links between immune cell dysfunction and cardiometabolic disease in psoriasis. In this review, we describe the role of potential common immunological mechanisms underlying both psoriasis and atherogenesis. We primarily discuss innate and adaptive immune cell subsets and their contributions to psoriatic disease and cardiovascular morbidity. Emerging efforts should focus on understanding the interplay among immune cells, adipose tissue, and various biomarkers of immune dysfunction to provide direction for future targeted therapy.
- Subjects :
- Adaptive Immunity
Adipose Tissue immunology
Adipose Tissue metabolism
Animals
Biological Products therapeutic use
Biomarkers
Cardiovascular Diseases therapy
Chronic Disease
Cytokines metabolism
Disease Susceptibility
Humans
Immunity, Innate
Inflammation complications
Inflammation immunology
Psoriasis therapy
Cardiovascular Diseases complications
Cardiovascular Diseases immunology
Psoriasis complications
Psoriasis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29910818
- Full Text :
- https://doi.org/10.3389/fimmu.2018.01234