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Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients.
- Source :
-
BMC cancer [BMC Cancer] 2018 Jun 08; Vol. 18 (1), pp. 644. Date of Electronic Publication: 2018 Jun 08. - Publication Year :
- 2018
-
Abstract
- Background: This study aimed to investigate the efficacy and safety of drug eluting beads transarterial chemoembolization (DEB-TACE) treatment by CalliSpheres® in Chinese patients with hepatocellular carcinoma (HCC) as well as the predicting factors for response.<br />Methods: 99 patients with HCC were consecutively enrolled in this study. All participants were treated by CalliSpheres® DEB-TACE. Clinical response was evaluated according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. Common Terminology Criteria for Adverse Events (CTCAE) was used to assess the adverse events and liver dysfunction during and after the operation.<br />Results: Post treatment, 16 patients (16.2%) achieved CR and 59 (59.6%) achieved PR, the ORR was 75.8%. Subgroup analysis showed that patients with higher BCLC stage were of worse CR and ORR rates, and the CR as well as ORR between patients with cTACE history and patients without cTACE history were similar. Univariate logistic regression analysis displayed that number of nodules > 3, higher BCLC stage and previous cTACE might be correlated with worse ORR but with no statistical significance. As to liver function, CTCAE grades of laboratory indexes for liver function were increased at 1 week compared to baseline and recovered to the baseline grades at 1-3 months post operation. Besides, most of the common adverse events were light and moderate in our study.<br />Conclusions: In conclusion, DEB-TACE by CalliSpheres® was efficient and well tolerated in Chinese HCC patients, and BCLC stage, number of nodules and cTACE history were possibly correlated with treatment response.
- Subjects :
- Adult
Aged
Antibiotics, Antineoplastic administration & dosage
Asian People
Doxorubicin administration & dosage
Epirubicin administration & dosage
Female
Humans
Male
Microspheres
Middle Aged
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Carcinoma, Hepatocellular therapy
Chemoembolization, Therapeutic methods
Drug Delivery Systems methods
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 29914435
- Full Text :
- https://doi.org/10.1186/s12885-018-4566-4