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GeNets: a unified web platform for network-based genomic analyses.

Authors :
Li T
Kim A
Rosenbluh J
Horn H
Greenfeld L
An D
Zimmer A
Liberzon A
Bistline J
Natoli T
Li Y
Tsherniak A
Narayan R
Subramanian A
Liefeld T
Wong B
Thompson D
Calvo S
Carr S
Boehm J
Jaffe J
Mesirov J
Hacohen N
Regev A
Lage K
Source :
Nature methods [Nat Methods] 2018 Jul; Vol. 15 (7), pp. 543-546. Date of Electronic Publication: 2018 Jun 18.
Publication Year :
2018

Abstract

Functional genomics networks are widely used to identify unexpected pathway relationships in large genomic datasets. However, it is challenging to compare the signal-to-noise ratios of different networks and to identify the optimal network with which to interpret a particular genetic dataset. We present GeNets, a platform in which users can train a machine-learning model (Quack) to carry out these comparisons and execute, store, and share analyses of genetic and RNA-sequencing datasets.

Details

Language :
English
ISSN :
1548-7105
Volume :
15
Issue :
7
Database :
MEDLINE
Journal :
Nature methods
Publication Type :
Academic Journal
Accession number :
29915188
Full Text :
https://doi.org/10.1038/s41592-018-0039-6