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Characteristics and survival outcomes related to the infra-pyloric lymph node status of gastric cancer patients.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2018 Jun 20; Vol. 16 (1), pp. 116. Date of Electronic Publication: 2018 Jun 20. - Publication Year :
- 2018
-
Abstract
- Background: To study metastasis to the infra-pyloric (no. 6) lymph nodes and their subgroups and the related risk factors of gastric cancer patients.<br />Methods: Gastric cancer patients who underwent gastrectomy with complete postoperative pathological information on the no. 6 lymph node station and its subgroups from January 1, 2008, to December 31, 2011, were included. The clinicopathological characteristics and survival outcomes were analyzed.<br />Results: A total of 121 patients were included; they had 6.1 ± 7.7 positive lymph nodes, and 35.1 ± 14.2 lymph nodes were examined. The overall lymph node positivity rate was 67.8% (82/121) with a positivity rate of 28.1% (34/121) for the no. 6 lymph nodes. The metastasis rate was 6.6% for the no. 6a nodes, 6.6% for the no. 6b nodes, and 21.5% for the no. 6c nodes. Also, no. 8a (OR = 1.329, p = 0.017) and no. 9 (OR = 1.250, p = 0.022) nodal positivity and lower third tumor location (OR = 1.278, p = 0.001) were independent risk factors for no. 6 lymph nodal metastasis. There was a significant survival difference between patients with positive and negative no. 6 lymph nodes and patients with metastasis to other lymph node stations (p <  0.001).<br />Conclusions: Patients with no. 6 lymph node metastasis have poor survival outcomes. Complete infra-pyloric lymphadenectomy is necessary and crucial for gastric cancer patients.
- Subjects :
- Adenocarcinoma drug therapy
Adenocarcinoma mortality
Adenocarcinoma surgery
Adult
Aged
Female
Gastrectomy
Humans
Lymph Node Excision
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Prognosis
Registries
Retrospective Studies
Stomach Neoplasms drug therapy
Stomach Neoplasms mortality
Stomach Neoplasms surgery
Adenocarcinoma pathology
Lymph Nodes pathology
Pyloric Antrum pathology
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 29925390
- Full Text :
- https://doi.org/10.1186/s12957-018-1412-8