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Diagnostic and Prognostic Value of Talin-1 and Midkine as Tumor Markers in Hepatocellular Carcinoma in Egyptian Patients
- Source :
-
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2018 Jun 25; Vol. 19 (6), pp. 1503-1508. Date of Electronic Publication: 2018 Jun 25. - Publication Year :
- 2018
-
Abstract
- Background: Hepatocellular carcinoma (HCC) is a main cause of cancer death all over the world. Treatment and outcome of HCC based on its early diagnosis. This study was conducted to estimate the role of talin-1 and midkine in combination with total antioxidant capacity (TAC) as tumor markers in HCC patients. Methods: Serum levels of talin-1 and midkine were measured in 90 Egyptian subjects including 44 patients with HCC, 31patients with cirrhosis and 15 healthy controls using enzyme-linked immunosorbent assay (ELISA) technique. While a colorimetric method was used for measurement of TAC. Results: Serum talin-1 in HCC patients was significantly lower than that in patients with cirrhosis (P<0.001) and normal control (P<0.001). In addition, increased invasion and metastasis correlated with reduced talin-1 level. Serum midkine in HCC patients was significantly higher compared to cirrhotic patients (P<0.001) and normal control (P<0.001). Midkine at a cut off value of 1683 pg/ml showed a sensitivity of (81.82%) and specificity of (83.87%). While alpha-fetoprotein (AFP) at a cut off value of 200 ng/ml had a sensitivity of (52.27%), while specificity was (96.77%). Midkine was positive in 80.9% of HCC patients with negative AFP. Serum TAC was significantly decreased in HCC patients when compared with control group (P<0.001). Conclusion: Talin-1 may be implicated in the carcinogenesis and metastasis of HCC and can be used as a useful tumor marker for HCC. Midkine may be a potential diagnostic marker for HCC and may be used in addition to AFP to increase the sensitivity of HCC detection.<br /> (Creative Commons Attribution License)
- Subjects :
- Adult
Aged
Antioxidants metabolism
Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular therapy
Case-Control Studies
Egypt
Female
Follow-Up Studies
Humans
Liver Cirrhosis blood
Liver Cirrhosis therapy
Liver Neoplasms blood
Liver Neoplasms therapy
Lymphatic Metastasis
Male
Middle Aged
Midkine
Prognosis
ROC Curve
Survival Rate
Biomarkers, Tumor blood
Carcinoma, Hepatocellular secondary
Intercellular Signaling Peptides and Proteins blood
Liver Cirrhosis pathology
Liver Neoplasms pathology
Talin blood
Subjects
Details
- Language :
- English
- ISSN :
- 2476-762X
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Asian Pacific journal of cancer prevention : APJCP
- Publication Type :
- Academic Journal
- Accession number :
- 29936723
- Full Text :
- https://doi.org/10.22034/APJCP.2018.19.6.1503