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Feasibility and diagnostic performance of hybrid PET/MRI compared with PET/CT for gynecological malignancies: a prospective pilot study.
- Source :
-
Abdominal radiology (New York) [Abdom Radiol (NY)] 2018 Dec; Vol. 43 (12), pp. 3462-3467. - Publication Year :
- 2018
-
Abstract
- Purpose: The purpose of the study was to assess the feasibility and diagnostic performance of FDG-PET/MR imaging compared to PET/CT for staging of patients with a gynecological malignancy.<br />Methods: 25 patients with a gynecological malignancy were prospectively enrolled into this pilot study. Patients underwent sequential full-body PET/CT and PET/MR of the abdomen and pelvis after administration of a single dose of F-18 FDG. PET/MRI and PET/CT images were independently reviewed by two expert radiologists. Readers were blinded to the results of the other imaging procedures. Clinical and pathologic information was abstracted from medical charts.<br />Results: 18 patients were included in the final analysis with a median age of 62 years (range 31-88). 61% of patients (11/18) had cervical cancer, while the remaining patients had endometrial cancer. PET/MRI as compared to PET/CT detected all primary tumors, 7/7 patients with regional lymph nodes, and 1/1 patient with an abdominal metastasis. Two patients had additional lymph nodes outside of the abdominopelvic cavity detected on PET/CT that were not seen on PET/MRI, whereas 6 patients had parametrial invasion and one patient had invasion of the bladder seen on PET/MRI not detected on PET/CT. Five cervical cancer patients had discordant clinical vs. radiographic staging based on PET/MRI detection of soft tissue involvement. Management changed for two patients who had clinical stage IB1 and radiographic stage IIB cervical cancer.<br />Conclusions: PET/MRI is feasible and has at least comparable diagnostic ability to PET/CT for identification of primary cervical and endometrial tumors and regional metastases. PET/MRI may be superior to PET/CT for initial radiographic assessment of cervical cancers.
- Subjects :
- Adult
Aged
Aged, 80 and over
Feasibility Studies
Female
Humans
Middle Aged
Pilot Projects
Positron-Emission Tomography methods
Prospective Studies
Tomography, X-Ray Computed methods
Magnetic Resonance Imaging methods
Multimodal Imaging methods
Positron Emission Tomography Computed Tomography methods
Uterine Neoplasms diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2366-0058
- Volume :
- 43
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Abdominal radiology (New York)
- Publication Type :
- Academic Journal
- Accession number :
- 29948057
- Full Text :
- https://doi.org/10.1007/s00261-018-1665-2