Back to Search
Start Over
Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Jun 26; Vol. 19 (7). Date of Electronic Publication: 2018 Jun 26. - Publication Year :
- 2018
-
Abstract
- Two transition metal complexes with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (L), [Cu(L)Cl₂]₂ ( 1 ) and [Ni(L)Cl₂]·CH₂Cl₂ ( 2 ), were synthesized and fully characterized. Complex 1 exhibited high in vitro antitumor activity against SK-OV-3, MGC80-3 and HeLa cells with IC <subscript>50</subscript> values of 3.69 ± 0.16, 2.60 ± 0.17, and 3.62 ± 0.12 μM, respectively. In addition, complex 1 caused cell arrest in the S phase, which led to the down-regulation of Cdc25 A, Cyclin B, Cyclin A, and CDK2, and the up-regulation of p27, p21, and p53 proteins in MGC80-3 cells. Complex 1 induced MGC80-3 cell apoptosis via a mitochondrial dysfunction pathway, as shown by the significantly decreased level of bcl-2 protein and the loss of Δψ, as well as increased levels of reactive oxygen species (ROS), intracellular Ca <superscript>2+</superscript> , cytochrome C, apaf-1, caspase-3, and caspase-9 proteins in MGC80-3 cells.
- Subjects :
- Antineoplastic Agents chemistry
Apoptosis drug effects
Calcium metabolism
Caspases metabolism
Cell Cycle drug effects
Cell Cycle Proteins metabolism
Cell Line, Tumor
Coordination Complexes chemistry
Crystallography, X-Ray
Enzyme Activation drug effects
Humans
Hydrazones chemistry
Inhibitory Concentration 50
Intracellular Space metabolism
Membrane Potential, Mitochondrial drug effects
Reactive Oxygen Species metabolism
Solutions
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Coordination Complexes chemical synthesis
Coordination Complexes pharmacology
Copper chemistry
Hydrazones chemical synthesis
Hydrazones pharmacology
Nickel chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29949884
- Full Text :
- https://doi.org/10.3390/ijms19071874