Back to Search
Start Over
Microencapsulation and the Characterization of Polyherbal Formulation (PHF) Rich in Natural Polyphenolic Compounds.
- Source :
-
Nutrients [Nutrients] 2018 Jun 28; Vol. 10 (7). Date of Electronic Publication: 2018 Jun 28. - Publication Year :
- 2018
-
Abstract
- Microencapsulation of polyherbal formulation (PHF) extract was carried out by freeze drying method, by employing gum arabic (GA), gelatin (GE), and maltodextrin (MD) with their designated different combinations as encapsulating wall materials. Antioxidant components (i.e., total phenolic contents (TPC), total flavonoids contents (TFC), and total condensed tannins (TCT)), antioxidant activity (i.e., DPPH, &beta;-carotene & ABTS⁺ assays), moisture contents, water activity (a <subscript>w</subscript> ), solubility, hygroscopicity, glass transition temperature (T <subscript>g</subscript> ), particle size, morphology, in vitro&alpha;-amylase and &alpha;-glucosidase inhibition and bioavailability ratios of the powders were investigated. Amongst all encapsulated products, T <subscript>B</subscript> (5% GA & 5% MD) and T <subscript>C</subscript> (10% GA) have proven to be the best treatments with respect to the highest preservation of antioxidant components. These treatments also exhibited higher antioxidant potential by DPPH and &beta;-carotene assays and noteworthy for an ABTS⁺ assays. Moreover, the aforesaid treatments also demonstrated lower moisture content, a <subscript>w</subscript> , particle size and higher solubility, hygroscopicity and glass transition temperature (T <subscript>g</subscript> ). All freeze dried samples showed irregular (asymmetrical) microcrystalline structures. Furthermore, T <subscript>B</subscript> and T <subscript>C</subscript> also illustrated the highest in vitro anti-diabetic potential due to great potency for inhibiting &alpha;-amylase and &alpha;-glucosidase activities. In the perspective of bioavailability, T <subscript>A</subscript> , T <subscript>B</subscript> and T <subscript>C</subscript> demonstrated the excellent bioavailability ratios (%). Furthermore, the photochemical profiling of ethanolic extract of PHF was also revealed to find out the bioactive compounds.
- Subjects :
- Administration, Oral
Animals
Antioxidants administration & dosage
Antioxidants chemistry
Antioxidants pharmacokinetics
Benzothiazoles chemistry
Biological Availability
Biphenyl Compounds chemistry
Drug Compounding
Freeze Drying
Glycoside Hydrolase Inhibitors administration & dosage
Glycoside Hydrolase Inhibitors chemistry
Glycoside Hydrolase Inhibitors pharmacokinetics
Mice
Particle Size
Picrates chemistry
Plant Preparations administration & dosage
Plant Preparations chemistry
Plant Preparations pharmacokinetics
Polyphenols administration & dosage
Polyphenols chemistry
Polyphenols pharmacokinetics
Powders
Solubility
Sulfonic Acids chemistry
Technology, Pharmaceutical methods
Transition Temperature
Wettability
alpha-Amylases antagonists & inhibitors
alpha-Amylases metabolism
beta Carotene chemistry
Antioxidants pharmacology
Glycoside Hydrolase Inhibitors pharmacology
Plant Preparations pharmacology
Polyphenols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 29958444
- Full Text :
- https://doi.org/10.3390/nu10070843