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C. elegans -An Emerging Model to Study Metal-Induced RAGE-Related Pathologies.
- Source :
-
International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Jul 04; Vol. 15 (7). Date of Electronic Publication: 2018 Jul 04. - Publication Year :
- 2018
-
Abstract
- The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
Details
- Language :
- English
- ISSN :
- 1660-4601
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of environmental research and public health
- Publication Type :
- Academic Journal
- Accession number :
- 29973513
- Full Text :
- https://doi.org/10.3390/ijerph15071407