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Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
- Source :
-
EMBO molecular medicine [EMBO Mol Med] 2018 Aug; Vol. 10 (8). - Publication Year :
- 2018
-
Abstract
- Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.<br /> (© 2018 The Authors. Published under the terms of the CC BY 4.0 license.)
- Subjects :
- Animals
Blood Glucose metabolism
Epigenesis, Genetic
Glycolysis
Humans
Hyperglycemia metabolism
Hypoglycemia metabolism
Hypoxia metabolism
Inflammation metabolism
Ketone Bodies biosynthesis
Lipolysis
Metabolic Networks and Pathways
Mice
Mitochondria metabolism
Peroxisome Proliferator-Activated Receptors metabolism
Rats
Sepsis blood
Sepsis diagnosis
Sepsis genetics
Sepsis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1757-4684
- Volume :
- 10
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- EMBO molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29976786
- Full Text :
- https://doi.org/10.15252/emmm.201708712