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Expression of G α q Is Decreased in Lymphocytes from Primary Sjögren's Syndrome Patients and Related to Increased IL-17A Expression.
- Source :
-
Journal of immunology research [J Immunol Res] 2018 Jun 07; Vol. 2018, pp. 8212641. Date of Electronic Publication: 2018 Jun 07 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Primary Sjögren's syndrome (pSS) is a rheumatic disease characterized by the destruction of salivary and lacrimal glands, and its pathogenesis mechanism remains unclear. G α q is the α -subunit of the heterotrimeric Gq protein. Researches demonstrated that G α q was involved in the pathogenesis regulation of several rheumatic diseases. This study explored the role of G α q in pSS. G α q mRNA levels in peripheral blood mononuclear cells (PBMCs) from 39 patients and 26 healthy controls (HCs) were investigated using real-time PCR. IL-17A serum concentrations in 22 pSS patients and 23 HCs were tested by ELISA, and the clinical significance of G α q was analyzed. The association of G α q with interleukin-17A (IL-17A) expression was also analyzed in patients with pSS. We showed that G α q expression in PBMCs from patients with pSS was significantly lower than that in PBMCs from HCs. G α q expression level was closely associated with pSS disease activity. Furthermore, a negative association was also found in IL-17A and G α q expression level. These data suggest that G α q is involved in pSS pathogenesis regulation, possibly due to its regulation of Th17. These results provide new insights into the pSS pathogenesis mechanism involving abnormal Th17 regulation.
- Subjects :
- Adult
Biomarkers
Case-Control Studies
Female
GTP-Binding Protein alpha Subunits, Gq-G11 blood
GTP-Binding Protein alpha Subunits, Gq-G11 genetics
Humans
Interleukin-17 blood
Leukocytes, Mononuclear immunology
Male
Middle Aged
RNA, Messenger metabolism
Sjogren's Syndrome genetics
Sjogren's Syndrome metabolism
Th17 Cells immunology
GTP-Binding Protein alpha Subunits, Gq-G11 metabolism
Interleukin-17 metabolism
Leukocytes, Mononuclear metabolism
Sjogren's Syndrome immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2314-7156
- Volume :
- 2018
- Database :
- MEDLINE
- Journal :
- Journal of immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 29977933
- Full Text :
- https://doi.org/10.1155/2018/8212641