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Retinal perfusion changes in radiation retinopathy.
- Source :
-
Acta ophthalmologica [Acta Ophthalmol] 2018 Sep; Vol. 96 (6), pp. e727-e731. Date of Electronic Publication: 2018 Jul 11. - Publication Year :
- 2018
-
Abstract
- Purpose: To investigate retinal blood flow and oxygen saturation changes in patients diagnosed with retinopathy following plaque radiation treatment to treat choroidal melanoma.<br />Methods: Eight patients (mean age 55.75 years, SD 12.58 years) who have developed unilateral ischaemic radiation-related retinopathy as confirmed by wide-field fluorescein angiography were recruited for the study. The fellow eye with no other ocular or retinal pathology was used as control. Both eyes underwent measurement of total retinal blood flow (TRBF) and retinal blood oxygen saturation using prototype methodologies of Doppler Spectral Domain Optical Coherence Tomography (OCT) and Hyperspectral Retinal Camera, respectively.<br />Results: The average TRBF in the retinopathy eye was significantly lower compared to the fellow eye (33.48 ± 12.73 μl/min versus 50.37 ± 15.26 μl/min; p = 0.013). The arteriolar oxygen saturation (SaO <subscript>2</subscript> ) and venular oxygen saturation (SvO <subscript>2</subscript> ) were higher in the retinopathy eye compared to the fellow eye (101.11 ± 4.26%, versus 94.45 ± 5.79%; p = 0.008) and (62.96 ± 11.05% versus 51.24 ± 6.88%, p = 0.051), respectively.<br />Conclusion: The ionizing radiation seems to have an impact on the TRBF, SaO <subscript>2</subscript> and SvO <subscript>2</subscript> , clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy.<br /> (© 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)
- Subjects :
- Choroid Neoplasms radiotherapy
Disease Progression
Female
Fundus Oculi
Humans
Melanoma radiotherapy
Middle Aged
Radiation Injuries diagnosis
Radiation Injuries physiopathology
Retinal Diseases diagnosis
Retinal Diseases etiology
Retinal Vessels diagnostic imaging
Retinal Vessels radiation effects
Fluorescein Angiography methods
Radiation Injuries complications
Regional Blood Flow physiology
Retinal Diseases physiopathology
Retinal Vessels physiopathology
Tomography, Optical Coherence methods
Subjects
Details
- Language :
- English
- ISSN :
- 1755-3768
- Volume :
- 96
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta ophthalmologica
- Publication Type :
- Academic Journal
- Accession number :
- 29998553
- Full Text :
- https://doi.org/10.1111/aos.13797