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Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis.
- Source :
-
Asian journal of andrology [Asian J Androl] 2018 Nov-Dec; Vol. 20 (6), pp. 593-599. - Publication Year :
- 2018
-
Abstract
- Testicular microlithiasis (TM) is one of the symptoms of testicular dysgenesis syndrome (TDS). TM is particularly interesting as an informative marker of testicular germ cell tumors (TGCTs). KIT ligand gene (KITLG), BCL2 antagonist/killer 1 (BAK1), and sprouty RTK signaling antagonist 4 (SPRY4) genes are associated with a high risk of TGCTs, whereas bone morphogenetic protein 7 gene (BMP7), transforming growth factor beta receptor 3 gene (TGFBR3), and homeobox D cluster genes (HOXD) are related to TDS. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated allele and genotype frequencies for KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876), BAK1 (rs210138), BMP7 (rs388286), TGFBR3 (rs12082710), and HOXD (rs17198432) in 142 TGCT patients, 137 TM patients, and 153 fertile men (control group). We found significant differences in the KITLG GG&#95;rs995030 genotype in TM (P = 0.01) and TGCT patients (P = 0.0005) compared with the control. We also revealed strong associations between KITLG&#95;rs1508595 and TM (G allele, P = 0.003; GG genotype, P = 0.01) and between KITLG&#95;rs1508595 and TGCTs (G allele, P = 0.0001; GG genotype, P = 0.0007). Moreover, there was a significant difference in BMP7&#95;rs388286 between the TGCT group and the control (T allele, P = 0.00004; TT genotype, P = 0.00006) and between the TM group and the control (T allele, P = 0.04). HOXD also demonstrated a strong association with TGCTs (rs17198432 A allele, P = 0.0001; AA genotype, P = 0.001). Furthermore, significant differences were found between the TGCT group and the control in the BAK1&#95;rs210138 G allele (P = 0.03) and the GG genotype (P = 0.01). KITLG and BMP7 genes, associated with the development of TGCTs, may also be related to TM. In summary, the KITLG GG&#95;rs995030, GG&#95;rs1508595, BMP7 TT&#95;rs388286, HOXD AA&#95;rs17198432, and BAK1 GG&#95;rs210138 genotypes were associated with a high risk of TGCT development.<br />Competing Interests: None
- Subjects :
- Adolescent
Adult
Calculi complications
Calculi diagnostic imaging
Case-Control Studies
Cohort Studies
DNA genetics
Gene Frequency
Genetic Predisposition to Disease
Gonadal Dysgenesis complications
Humans
Male
Neoplasms, Germ Cell and Embryonal complications
Polymerase Chain Reaction
Testicular Diseases complications
Testicular Diseases diagnostic imaging
Testicular Neoplasms complications
Ultrasonography
Young Adult
Calculi genetics
Gonadal Dysgenesis genetics
Neoplasms, Germ Cell and Embryonal genetics
Testicular Diseases genetics
Testicular Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1745-7262
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Asian journal of andrology
- Publication Type :
- Academic Journal
- Accession number :
- 30027931
- Full Text :
- https://doi.org/10.4103/aja.aja_54_18