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Selective bio-labeling and induced apoptosis of hematopoietic cancer cells using dual-functional polyethylenimine-caged platinum nanoclusters.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Sep 10; Vol. 503 (3), pp. 1465-1470. Date of Electronic Publication: 2018 Jul 18. - Publication Year :
- 2018
-
Abstract
- In the past decades, platinum (Pt) is employed to clinical treatment of various cancers. However, for Pt-based drugs, especially Pt in +2 state [Pt (II)], such as cisplatin, number of drawbacks impede their anticancer efficiency including poor pharmacology, fast blood clearance, systemic toxicities causing from poor specificity and excretion of drug through kidneys. Herein, we developed dual-functional ultrafine polyethylenimine caged platinum nanoclusters (PEI-caged Pt NCs), which were utilized in biological imaging of the suspension cells system as fluorescent markers, and selective inhibition of hematopoietic malignancies as anticancer chemotherapeutics simultaneously. These zerovalent Pt NCs are capable to selectively enter into blood cancer cells (K562, BV173 cell lines) when compared to the peripheral blood mononucleated cells (PBMCs) from healthy donors, in addition, it can specifically induce pro-apoptotic protein expression (p53, PUMA, cleaved caspase) in hematopoietic cancer cells and promote cell apoptosis. Avoiding the adding of other fluorescent bio-markers, these Pt NCs showed great potential in diagnosis and treatment of hematopoietic system disease, such as acute myeloid leukemia, lymphoma, myeloma, etc.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Agents chemistry
Cell Proliferation drug effects
Drug Screening Assays, Antitumor
Hematologic Neoplasms pathology
Humans
Organoplatinum Compounds chemistry
Particle Size
Platinum chemistry
Polyethyleneimine chemistry
Tumor Cells, Cultured
Antineoplastic Agents pharmacology
Apoptosis drug effects
Hematologic Neoplasms drug therapy
Metal Nanoparticles chemistry
Organoplatinum Compounds pharmacology
Platinum pharmacology
Polyethyleneimine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 503
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 30029883
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.07.064