Back to Search
Start Over
Optimization and characterization of electrospun polycaprolactone coated with gelatin-silver nanoparticles for wound healing application.
- Source :
-
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2018 Oct 01; Vol. 91, pp. 318-329. Date of Electronic Publication: 2018 May 19. - Publication Year :
- 2018
-
Abstract
- Bacterial infection and damage caused by dressing removal are two concerning problems which prolong the healing process in treatment of skin injuries. In this study, plasma treated electrospun polycaprolactone (PCL) scaffold was coated with silver nanoparticles (AgNPs) embedded in gelatin (Gel) by multi-immersion technique to optimize its antibacterial performance and reduce wound-scaffold adhesion. Water interaction test was used to examine the hydrophilization of PCL electrospun fibers after plasma treatment. Scanning Electron Microscopy (SEM) and weight calculation were employed to investigate the morphology and absorptive ability of the GelAg multi-coated PCL membrane (EsPCLGelAg). Antibacterial property of the membrane was evaluated using agar diffusion method against gram positive and gram negative bacteria. Mice model was also used to examine the efficiency of the membrane in healing process and its ability to prevent damage of newly formed tissue when peeling off. SEM results showed that the thickness of GelAg layer on EsPCL membrane increases correspondingly to the number of coating times. In vitro and in vivo data also demonstrated that the greater number of GelAg coating times, the more significant the antibacterial property of the membrane while not sticking to the wound site. These results suggest that multi-coating technique can be applied to optimize the antibacterial property of EsPCLGelAg scaffold and prevent removal-induced damage for wound dressing applications.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Bandages
Female
Male
Mice
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Gelatin chemistry
Gelatin pharmacology
Metal Nanoparticles chemistry
Metal Nanoparticles therapeutic use
Polyesters chemistry
Polyesters pharmacology
Silver chemistry
Silver pharmacology
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0191
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Materials science & engineering. C, Materials for biological applications
- Publication Type :
- Academic Journal
- Accession number :
- 30033261
- Full Text :
- https://doi.org/10.1016/j.msec.2018.05.039