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FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy1.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2018; Vol. 65 (1), pp. 79-88. - Publication Year :
- 2018
-
Abstract
- Background: Our group has shown that in vivo tau brain binding patterns from FDDNP-PET scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in Alzheimer's disease (AD) patients and cognitively-intact controls.<br />Objective: To compare these findings with those from military personnel with histories of mild traumatic brain injury(mTBI).<br />Methods: FDDNP-PET brain scans were compared among 7 military personnel and 15 retired players with mTBI histories and cognitive and/or mood symptoms, 24 AD patients, and 28 cognitively-intact controls. Nonparametric ANCOVAs with Tukey-Kramer adjusted post-hoc comparisons were used to test for significant differences in regional FDDNP binding among subject groups.<br />Results: FDDNP brain binding was higher in military personnel compared to controls in the amygdala, midbrain, thalamus, pons, frontal and anterior and posterior cingulate regions (p < 0.01-0.0001). Binding patterns in the military personnel were similar to those of the players except for the amygdala and striatum (binding higher in players; p = 0.02-0.003). Compared with the AD group, the military personnel showed higher binding in the midbrain (p = 0.0008) and pons (p = 0.002) and lower binding in the medial temporal, lateral temporal, and parietal regions (all p = 0.02).<br />Conclusion: This first study of in vivo tau and amyloid brain signals in military personnel with histories of mTBI shows binding patterns similar to those of retired football players and distinct from the binding patterns in AD and normal aging, suggesting the potential value of FDDNP-PET for early detection and treatment monitoring in varied at-risk populations.
- Subjects :
- Aged
Alzheimer Disease diagnostic imaging
Athletic Injuries diagnostic imaging
Brain drug effects
Chronic Traumatic Encephalopathy complications
Cognition Disorders diagnostic imaging
Cognition Disorders etiology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Military Personnel
Nitriles pharmacokinetics
Protein Binding drug effects
Statistics, Nonparametric
United States
Brain diagnostic imaging
Brain metabolism
Chronic Traumatic Encephalopathy diagnostic imaging
Positron-Emission Tomography
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 65
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 30040711
- Full Text :
- https://doi.org/10.3233/JAD-171152