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The Emerging Importance of Liver Sinusoidal Endothelial Cells in Regulating Injury during Machine Perfusion of Deceased Liver Donors.
- Source :
-
Seminars in liver disease [Semin Liver Dis] 2018 Aug; Vol. 38 (3), pp. 252-259. Date of Electronic Publication: 2018 Jul 24. - Publication Year :
- 2018
-
Abstract
- While majority of liver transplants worldwide continue to be performed using deceased donor organs, the demands for donor livers continues to exceed the current supply. In an attempt to maximize the number of potentially usable donor livers and expand the current donor pool, there is intense global research by various groups exploring the role of machine perfusion in the liver transplantation, particularly with respect to the machine perfusion of extended-criteria liver donors. In this review, the authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cell may improve the quality of donor livers.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Animals
Donor Selection
Endothelial Cells metabolism
Endothelial Cells pathology
Graft Survival
Humans
Liver metabolism
Liver pathology
Liver Transplantation adverse effects
Organ Preservation adverse effects
Organ Preservation instrumentation
Perfusion adverse effects
Perfusion instrumentation
Reperfusion Injury etiology
Reperfusion Injury metabolism
Reperfusion Injury pathology
Risk Factors
Signal Transduction
Treatment Outcome
Waiting Lists
Endothelial Cells transplantation
Liver surgery
Liver Transplantation methods
Organ Preservation methods
Perfusion methods
Reperfusion Injury prevention & control
Tissue Donors supply & distribution
Subjects
Details
- Language :
- English
- ISSN :
- 1098-8971
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Seminars in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 30041277
- Full Text :
- https://doi.org/10.1055/s-0038-1661371