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Association Between the SNP rs143383 + 104T/C in the GDF5 Gene and the Risk of Knee Osteoarthritis in a Population from Northern Mexico-A Case-Control Study.
- Source :
-
Genetic testing and molecular biomarkers [Genet Test Mol Biomarkers] 2018 Aug; Vol. 22 (8), pp. 503-506. Date of Electronic Publication: 2018 Jul 25. - Publication Year :
- 2018
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Abstract
- Background: Previous studies have found an association between the SNP rs143383 + 104T/C in the growth differentiation factor 5 (GDF5) gene and the risk of developing knee osteoarthritis (KOA) in various populations worldwide.<br />Objective: To discover if there is an association between the SNP rs143383 + 104T/C, in the GDF5 gene and the risk of developing KOA in individuals from northern Mexico.<br />Methods: We used a case-control study format that included 145 patients with KOA and 145 healthy controls unrelated to patients. A peripheral blood sample was taken for each of them to identify the SNP by means of real-time PCR according to standard protocols.<br />Results: We found a strong association between the TT genotype and the risk of developing KOA (OR = 1.7, 95% CI = 1.12-2.8, p = 0.014), but not in the heterozygous TC state (OR = 1.56, CI 95% = 0.58-4.17, p = 0.367).<br />Conclusion: The TT genotype of the SNP rs143383 increases the susceptibility to KOA in the population of northern Mexico, according to the recessive segregation model.
- Subjects :
- Aged
Alleles
Case-Control Studies
Female
Gene Frequency genetics
Genetic Association Studies
Genetic Predisposition to Disease genetics
Growth Differentiation Factor 5 metabolism
Humans
Male
Mexico epidemiology
Middle Aged
Polymorphism, Single Nucleotide genetics
Promoter Regions, Genetic genetics
Risk Factors
Growth Differentiation Factor 5 genetics
Osteoarthritis, Knee genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1945-0257
- Volume :
- 22
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Genetic testing and molecular biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 30044130
- Full Text :
- https://doi.org/10.1089/gtmb.2018.0142