Expression of aldolase A messenger RNAs in human adult and foetal tissues and in hepatoma.

Authors :: Mennecier F
Daegelen D
Schweighoffer F
Levin M
Kahn A
Source :: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1986 Feb 13; Vol. 134 (3), pp. 1093-100.
Publication Year :: 1986
Abstract: 3 specific cDNA clones for human aldolase A were isolated from a human muscle library. One of them was subcloned in M 13 phage, then used as a probe to investigate the patterns and the levels of aldolase A mRNA in various human tissues. Two mRNA species differing in length were observed. The lighter one -1550 bases- was found specific to skeletal muscle; its amount increased during muscle development. The heavier aldolase A mRNA -1650 bases- accounted for foetal and ubiquitous presence of aldolase A isozyme. The resurgence of aldolase A in hepatomas occurred through this latter mRNA species.

Subjects :: Animals
DNA analysis
DNA Restriction Enzymes
Fetus enzymology
Fructose-Bisphosphate Aldolase biosynthesis
Humans
Isoenzymes biosynthesis
Isoenzymes genetics
Muscles enzymology
Nucleic Acid Hybridization
Rats
Carcinoma, Hepatocellular enzymology
Fructose-Bisphosphate Aldolase genetics
Liver Neoplasms enzymology
RNA, Messenger physiology

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