Back to Search
Start Over
The association between the incidence of intestinal graft-vs-host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation.
- Source :
-
Clinical transplantation [Clin Transplant] 2018 Sep; Vol. 32 (9), pp. e13361. Date of Electronic Publication: 2018 Aug 13. - Publication Year :
- 2018
-
Abstract
- Intestinal microbiota plays an important role in the regulation of allogeneic immune reaction after allogeneic hematopoietic stem cell transplantation (allo-SCT). Intestinal graft-vs-host disease (GVHD) is one of the major causes of mortality after allo-SCT and often complicated with intestinal dysbiosis. Recent studies suggest that antibiotic-induced dysbiosis is a risk factor for intestinal GVHD. We retrospectively evaluated the impacts of antibiotic use on the incidence of intestinal GVHD occurring before day 100 after allo-SCT. Among 213 patients who underwent allo-SCT, 200 patients achieving engraftment were analyzed. Antibiotics were classified into carbapenem, quinolone, penicillin, cephem, and glycopeptide. Among 128 patients who developed acute GVHD, intestinal GVHD developed in 36 patients. Patients with intestinal GVHD received significantly longer administration of carbapenem and glycopeptide compared to those without it in periengraftment period. In multivariate analysis, use of carbapenem for greater than 7 days was associated with an increased risk of intestinal GVHD. However, use of antibiotics for greater than 7 days was not associated with poor overall survival and high nonrelapse mortality. Long use of carbapenem in periengraftment period may be a risk for intestinal GVHD. Prospective studies are required to validate our findings.<br /> (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Female
Follow-Up Studies
Graft vs Host Disease etiology
Graft vs Host Disease pathology
Humans
Intestinal Diseases microbiology
Japan epidemiology
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Young Adult
Anti-Bacterial Agents adverse effects
Gastrointestinal Microbiome drug effects
Graft vs Host Disease epidemiology
Hematologic Neoplasms therapy
Hematopoietic Stem Cell Transplantation adverse effects
Intestinal Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 30054935
- Full Text :
- https://doi.org/10.1111/ctr.13361