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Pharmacokinetics of alfaxalone infusions, context-sensitive half-time and recovery times in male neutered cats.
- Source :
-
Veterinary anaesthesia and analgesia [Vet Anaesth Analg] 2018 Sep; Vol. 45 (5), pp. 630-639. Date of Electronic Publication: 2018 Jun 30. - Publication Year :
- 2018
-
Abstract
- Objectives: To determine the context-sensitive half-time of alfaxalone following intravenous infusions of various durations. To estimate the time necessary for plasma concentration to decrease by up to 95%.<br />Study Design: Prospective randomized and simulation studies.<br />Animals: A group of six 1-year-old male castrated research cats.<br />Methods: Cats were instrumented with catheters in a jugular and a medial saphenous vein. Alfaxalone was administered using a target-controlled infusion system, to target a plasma alfaxalone concentration of 7.6 mg L <superscript>-1</superscript> . The infusion lasted 30 (n = 2), 60 (n = 2) or 240 (n = 2) minutes. Blood samples were collected prior to drug administration, and at several times during and up to 8 hours after the infusion, for the determination of plasma alfaxalone concentration using liquid chromatography/tandem mass spectrometry. Compartment models were fitted to each time-concentration profile, and a population model was fitted to data from all individuals. The context-sensitive half-time was determined from each individual model. In addition, times for plasma alfaxalone concentration to decrease by 50-95% following bolus administration and target-controlled infusions or continuous rate infusions of 0.5-8 hours were estimated by simulation using the population model.<br />Results: Context-sensitive half-times were 2 and 8, 6 and 9, and 18 and 20 minutes for the 30, 60 and 240 minutes, respectively. Time for plasma alfaxalone concentration to decrease by 90% was predicted to range from 7 to 120 or 113 minutes following a bolus to an 8 hour target-controlled or continuous rate infusion, respectively.<br />Conclusion and Clinical Relevance: Recovery time from alfaxalone anesthesia in cats is predicted to be influenced by the duration of target-controlled infusion.<br /> (Copyright © 2018 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Anesthesia Recovery Period
Anesthetics, Intravenous administration & dosage
Anesthetics, Intravenous blood
Animals
Cats
Half-Life
Infusions, Intravenous veterinary
Male
Pregnanediones administration & dosage
Pregnanediones blood
Anesthesia, Intravenous veterinary
Anesthetics, Intravenous pharmacokinetics
Pregnanediones pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1467-2995
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Veterinary anaesthesia and analgesia
- Publication Type :
- Academic Journal
- Accession number :
- 30057008
- Full Text :
- https://doi.org/10.1016/j.vaa.2018.06.003