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Evaluation of the concentrations of psychotropic drugs in HIV-infected versus HIV-negative patients: Potential implications for clinical practice.
- Source :
-
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2020 Oct; Vol. 21 (8), pp. 651-657. Date of Electronic Publication: 2018 Sep 20. - Publication Year :
- 2020
-
Abstract
- Objectives: The management of psychiatric illness in HIV-infected patients is clinically challenging because of the risk of potential drug-drug interactions. Here, we aimed to measure the antidepressant and/or antipsychotic drug concentrations in HIV-infected patients during routine outpatient visits. Methods: Six hundred HIV-infected patients were screened during the first 15 months after the introduction of our outpatient polytherapy management service in a search for subjects treated with psychotropic drugs for at least 3 months. The distribution of psychotropic drug concentrations in HIV-infected patients was compared with that observed in a control group of HIV-negative patients monitored over the same period. Results: The search identified 82 HIV-infected patients concomitantly receiving antiretroviral and psychotropic drug treatment, 55% of whom had plasma psychotropic drug concentrations that were below minimum effective levels. The same result was found in only 26% of the samples taken from HIV-negative patients. These results were not affected by patients' gender, age, adherence to therapies or drug-drug interactions. Conclusions: A higher rate of sub-therapeutic antidepressant and/or antipsychotic drugs concentrations were found in HIV-infected patients. The creation of multidiscliplinary specialist teams may contribute to improving the management of such complex patients.
- Subjects :
- Antidepressive Agents blood
Antidepressive Agents therapeutic use
Antipsychotic Agents blood
Antipsychotic Agents therapeutic use
Female
HIV Seropositivity blood
Humans
Male
Mental Disorders drug therapy
Middle Aged
Psychotropic Drugs therapeutic use
HIV Infections blood
HIV Seronegativity
Psychotropic Drugs blood
Subjects
Details
- Language :
- English
- ISSN :
- 1814-1412
- Volume :
- 21
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 30058430
- Full Text :
- https://doi.org/10.1080/15622975.2018.1500032