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Urinary miR-26b as a potential biomarker for patients with sepsis-associated acute kidney injury: a Chinese population-based study.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2018 Jul; Vol. 22 (14), pp. 4604-4610. - Publication Year :
- 2018
-
Abstract
- Objective: Acute kidney injury (AKI) is common in critically ill patients, and sepsis patients with AKI had a higher mortality rate. The aim of the present study was to determine the potential value of urinary miR-26b in the diagnosis of sepsis-associated AKI.<br />Patients and Methods: Urinary samples were collected from a cohort of 155 sepsis patients (68 AKI patients and 87 non-AKI patients) and 57 patients with non-infectious systemic inflammatory response syndrome (SIRS). The expression levels of urinary miR-26b were measured by RT-qPCR analysis. ROC curve analysis was performed to determine the diagnostic value. Pearson correlation analysis was performed to assess the levels of urinary miR-26b and several clinical parameters. Kaplan-Meier curves were plotted to show the impact of urinary miR-26b on the 28-day survival.<br />Results: Significantly increased urinary miR-26b levels were found in patients with sepsis-associated AKI. Urinary miR-26b had a sensitivity of 90.8% and specificity of 75.0% for distinguishing between AKI sepsis and non-AKI sepsis. Urinary miR-26b levels were closely correlated with clinical parameters reflecting the severity of the disease. Kaplan-Meier analysis revealed that sepsis patients with high urinary miR-26b levels had an elevated mortality rate.<br />Conclusions: Taken together, these findings suggested that urinary miR-26b might be utilized as a potential biomarker for sepsis-associated AKI.
- Subjects :
- Acute Kidney Injury etiology
Adult
Aged
Area Under Curve
C-Reactive Protein analysis
China
Cohort Studies
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
ROC Curve
Sensitivity and Specificity
Sepsis complications
Sepsis mortality
Acute Kidney Injury diagnosis
Biomarkers urine
MicroRNAs urine
Sepsis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 22
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30058697
- Full Text :
- https://doi.org/10.26355/eurrev_201807_15518