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Antibody to hepatitis B core antigen as a paradoxical marker for non-A, non-B hepatitis agents in donated blood.
- Source :
-
Annals of internal medicine [Ann Intern Med] 1986 Apr; Vol. 104 (4), pp. 488-95. - Publication Year :
- 1986
-
Abstract
- The relationship between the presence of antibody to hepatitis B core antigen (anti-HBc) in donor blood and the development of hepatitis in recipients of that blood was studied in 6293 blood donors and 481 recipients who were followed for 6 to 9 months after transfusion. Of 193 recipients of at least 1 unit of blood positive for anti-HBc, 23 (11.9%) developed non-A, non-B hepatitis compared with 12 (4.2%) of 288 recipients of only anti-HBc-negative blood (p less than 0.001). Donor anti-HBc status was not significantly associated with the development of hepatitis B in the recipient and was negatively associated with the development of cytomegalovirus hepatitis. The relationship of donor anti-HBc status and the development of non-A, non-B hepatitis in the recipient was independent of transfusion volume and elevated donor transaminase level. Although 88% of anti-HBc-positive blood units were not associated with recipient non-A, non-B hepatitis, calculation of maximal corrected efficacy predicted that exclusion of anti-HBc-positive donors might have prevented 43% of the cases of non-A, non-B hepatitis with a donor loss of 4%. Because of the serious chronic consequences of non-A, non-B hepatitis, surrogate tests for non-A, non-B virus carriers must be seriously considered.
- Subjects :
- Alanine Transaminase blood
Cardiac Surgical Procedures
Cytomegalovirus Infections immunology
Cytomegalovirus Infections transmission
Hepatitis B immunology
Hepatitis B transmission
Hepatitis C enzymology
Hepatitis C transmission
Hepatitis, Viral, Human transmission
Humans
Postoperative Complications immunology
Prospective Studies
Hepatitis B Antibodies analysis
Hepatitis B Core Antigens immunology
Hepatitis C immunology
Hepatitis, Viral, Human immunology
Transfusion Reaction
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4819
- Volume :
- 104
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 3006567
- Full Text :
- https://doi.org/10.7326/0003-4819-104-4-488