Regulatory status of N-alkylamide containing health products.

Authors :: Wynendaele E
De Spiegeleer B
Gevaert B
Janssens Y
Suleman S
Cattoor S
Saunders JH
Veryser L
Source :: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2018 Oct; Vol. 98, pp. 215-223. Date of Electronic Publication: 2018 Jul 30.
Publication Year :: 2018
Abstract: N-alkylamides (NAAs) are secondary metabolites occurring in more than 25 plant families. Plants containing NAAs are traditionally used in food for flavouring, tingling, pungent and saliva-enhancing properties but also to treat various diseases. NAA containing products are abundantly available on the market as food, cosmetics, medical devices and medicinal products. However, no unambiguous legal product classification is applied for these products. In this study, the different health product classes from a European viewpoint are discussed in relation to the pharmacokinetic and pharmacodynamic properties of the NAAs, their applied dosage and claimed usage.<br /> (Copyright © 2018. Published by Elsevier Inc.)