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Pluripotent stem cell replacement approaches to treat type 1 diabetes.
- Source :
-
Current opinion in pharmacology [Curr Opin Pharmacol] 2018 Dec; Vol. 43, pp. 20-26. Date of Electronic Publication: 2018 Jul 30. - Publication Year :
- 2018
-
Abstract
- Stem cells represent a potential candidate for β cell replacement in type 1 diabetes. Pluripotent stem cells are able to differentiate in vitro into functional insulin producing cells, that can restore normoglycemia in diabetic mice. Clinical trials with embryonic stem cell-derived pancreatic progenitors are ongoing. Besides, induced pluripotent stem cells offer the chance of personalized cell therapy. So far, transition to the clinic still needs to face critical issues, such as immunogenicity and safety of stem cell derived β cells. To this purpose, new strategies for immunoprotection, including micro and macro-encapsulation, but also gene editing approaches, are being explored.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation
Cell Proliferation
Cell Survival
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 pathology
Diabetes Mellitus, Type 1 physiopathology
Embryonic Stem Cells immunology
Embryonic Stem Cells metabolism
Graft Survival
Humans
Induced Pluripotent Stem Cells immunology
Induced Pluripotent Stem Cells metabolism
Insulin-Secreting Cells immunology
Insulin-Secreting Cells pathology
Islets of Langerhans Transplantation adverse effects
Phenotype
Regeneration
Risk Factors
Stem Cell Transplantation adverse effects
Treatment Outcome
Diabetes Mellitus, Type 1 surgery
Embryonic Stem Cells transplantation
Induced Pluripotent Stem Cells transplantation
Insulin-Secreting Cells metabolism
Islets of Langerhans Transplantation methods
Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4973
- Volume :
- 43
- Database :
- MEDLINE
- Journal :
- Current opinion in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30071348
- Full Text :
- https://doi.org/10.1016/j.coph.2018.07.007