Uridine derivatives from the seeds of Lepidium apetalum Willd. and their estrogenic effects.

Authors :: Li M
Zeng M
Zhang Z
Zhang J
Zhang B
Zhao X
Zheng X
Feng W
Source :: Phytochemistry [Phytochemistry] 2018 Nov; Vol. 155, pp. 45-52. Date of Electronic Publication: 2018 Jul 31.
Publication Year :: 2018
Abstract: Ten uridine derivatives (lepidiumuridine B-K) were isolated from the seeds of Lepidium apetalum Willd. Lepidiumuridine B-J were previously undescribed compounds, and were structurally characterized using analysis of their NMR and MS data. Lepidiumuridine C, D, I, and J increased cell proliferation and expression of ERα in the MCF-7 cell line. In addition, blockage of ERα completely abolished cell proliferation and expression of ERα in MCF-7 cells, suggesting that the proliferation effects of lepidiumuridine C, D, I, and J were ERα-mediated. The uridine derivatives might belong to undescribed phytoestrogens.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

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