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Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications.

Authors :
Brownstein AJ
Kostiuk V
Ziganshin BA
Zafar MA
Kuivaniemi H
Body SC
Bale AE
Elefteriades JA
Source :
Aorta (Stamford, Conn.) [Aorta (Stamford)] 2018 Feb; Vol. 6 (1), pp. 13-20. Date of Electronic Publication: 2018 Jul 27.
Publication Year :
2018

Abstract

Thoracic aortic aneurysms, with an estimated prevalence in the general population of 1%, are potentially lethal, via rupture or dissection. Over the prior two decades, there has been an exponential increase in our understanding of the genetics of thoracic aortic aneurysm and/or dissection (TAAD). To date, 30 genes have been shown to be associated with the development of TAAD and ∼30% of individuals with nonsyndromic familial TAAD have a pathogenic mutation in one of these genes. This review represents the authors' yearly update summarizing the genes associated with TAAD, including implications for the surgical treatment of TAAD. Molecular genetics will continue to revolutionize the approach to patients afflicted with this devastating disease, permitting the application of genetically personalized aortic care.<br />Competing Interests: The authors declare no conflict of interest related to this manuscript.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)

Details

Language :
English
ISSN :
2325-4637
Volume :
6
Issue :
1
Database :
MEDLINE
Journal :
Aorta (Stamford, Conn.)
Publication Type :
Academic Journal
Accession number :
30079932
Full Text :
https://doi.org/10.1055/s-0038-1639612