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Short Total Synthesis of Ajoene.

Authors :
Silva F
Khokhar SS
Williams DM
Saunders R
Evans GJS
Graz M
Wirth T
Source :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Sep 17; Vol. 57 (38), pp. 12290-12293. Date of Electronic Publication: 2018 Aug 19.
Publication Year :
2018

Abstract

We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3773
Volume :
57
Issue :
38
Database :
MEDLINE
Journal :
Angewandte Chemie (International ed. in English)
Publication Type :
Academic Journal
Accession number :
30079981
Full Text :
https://doi.org/10.1002/anie.201808605