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Does sucrose affect the glucose variability in patients with type 1 diabetes? a pilot crossover clinical study.
- Source :
-
Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2018 Nov; Vol. 55-56, pp. 179-184. Date of Electronic Publication: 2018 Jun 08. - Publication Year :
- 2018
-
Abstract
- Objective: The aim of this study was to compare the effects of a sucrose-free diet with a sucrose-added diet on glucose variability in patients with type 1 diabetes.<br />Methods: This was a two-way crossover design study in which patients with type 1 diabetes were monitored by blinded continuous glucose monitoring and were selected to receive a sucrose-free diet (<30 g/d), followed by a sucrose-added diet (>80 g/d) for 2 d each. Intra-day glucose variability was assessed by the mean amplitude of glycemic excursions (MAGE), the M-value, J-index, glycemic risk assessment in diabetes equation (GRADE), and continuous overlapping net glycemic action (CONGA <subscript>1-3</subscript> ). Between-day variability was determined by mean of daily difference (MODD). Statistical analyses were performed with a significance level of 5%.<br />Results: Ten patients with type 1 diabetes were evaluated. The participants were a mean of 26.1 ± 7.1 y of age. The mean duration of disease was 16.5 ± 10.5 y, and patients' mean glycated hemoglobin was 7.4% ± 0.8%. The intra- and inter-day glucose variability indexes did not differ between the diet periods (MAGE: 10.2 ± 5.1 and 10.4 ± 6.8mmol/L, P = 0.98; M-value: 12.9 ± 2 and 15.6 ± 1.3mmol/L, P = 0.29; J-index: 50.9 ± 4.4 and 57.7 ± 3.3mmol/L, P = 0.41; GRADE: 7.2 ± 1 and 4.7 ± 5.3mmol/L, P = 0.07; and MODD: 3.9 ± 1 and 4.3 ± 1.5mmol/L, P = 0.28; for the sucrose-free and sucrose-added diets, respectively). CONGA <subscript>1-3</subscript> were similar for both diet periods (P > 0.05).<br />Conclusions: The use of a moderate amount of sucrose, as part of a balanced diet, did not affect the glucose variability or insulin requirements in patients with type 1 diabetes.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Blood Glucose Self-Monitoring
Cross-Over Studies
Humans
Insulin blood
Insulin therapeutic use
Pilot Projects
Single-Blind Method
Treatment Outcome
Young Adult
Blood Glucose drug effects
Diabetes Mellitus, Type 1 blood
Diabetes Mellitus, Type 1 diet therapy
Diet methods
Dietary Sucrose pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1244
- Volume :
- 55-56
- Database :
- MEDLINE
- Journal :
- Nutrition (Burbank, Los Angeles County, Calif.)
- Publication Type :
- Academic Journal
- Accession number :
- 30086487
- Full Text :
- https://doi.org/10.1016/j.nut.2018.05.009