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A comparison of the effects of selective and non-selective mineralocorticoid antagonism on glucose homeostasis of heart failure patients with glucose intolerance or type II diabetes: A randomized controlled double-blind trial.
- Source :
-
American heart journal [Am Heart J] 2018 Oct; Vol. 204, pp. 190-195. Date of Electronic Publication: 2018 Jul 10. - Publication Year :
- 2018
-
Abstract
- Mineralocorticoid receptor antagonists (MRAs) decrease morbidity and mortality in patients with heart failure (HF). However, spironolactone, a non-selective MRA, has been shown to exert a harmful effect on glucose homeostasis. The objective of this multicenter, randomized, controlled, double-blind trial was to compare the effects of spironolactone to those of the selective MRA eplerenone on glucose homeostasis among 62 HF patients with glucose intolerance or type II diabetes. Trial registration number:NCT01586442.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Biomarkers blood
Biomarkers urine
Double-Blind Method
Eplerenone adverse effects
Female
Glycated Hemoglobin metabolism
Heart Failure complications
Heart Failure physiopathology
Humans
Insulin blood
Insulin Resistance
Male
Middle Aged
Mineralocorticoid Receptor Antagonists adverse effects
Prospective Studies
Spironolactone adverse effects
Stroke Volume
Blood Glucose metabolism
Diabetes Mellitus, Type 2 complications
Eplerenone therapeutic use
Glucose Intolerance complications
Heart Failure blood
Heart Failure drug therapy
Homeostasis
Mineralocorticoid Receptor Antagonists therapeutic use
Spironolactone therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6744
- Volume :
- 204
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Report
- Accession number :
- 30097164
- Full Text :
- https://doi.org/10.1016/j.ahj.2018.07.002