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Drug-loaded poly(L-lactide)/lignin stereocomplex film for enhancing stability and sustained release of trans-resveratrol.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2018 Nov; Vol. 119, pp. 1129-1136. Date of Electronic Publication: 2018 Aug 09. - Publication Year :
- 2018
-
Abstract
- We report a new drug-loaded film for blending poly(L-lactide) (PLLA) with lignin-based functional filler, which enhanced stability and sustained release of trans-resveratrol (trans-RSV). In addition, trans-RSV loaded PLLA/lignin films showed good antioxidant and anticancer effects. Incorporation of the optimized amount of lignin-based filler to PLLA matrix was key to achieve these desired functions. The lignin-based filler (LG-g-PDLA) was synthesized via ring-opening polymerization on alklin lignin with D-lactide. Benifiting from the stereocomplex formation (PLLA and PDLA side chains), similar polyphenolic structures between lignin and trans-RSV, and UV chromophoric groups of lignin, trans-RSV loaded PLLA/lignin-graft-PDLA films (R/P/LGPD) have good performances on mechanical property, uniformity distribution of drug, and light barrier property. The release behaviors of trans-RSV could be controlled by variation of LG-g-PDLA content. This system therefore offers great potential for the delivery of poor water soluble and light stability drugs.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents pharmacology
Antioxidants pharmacology
Cell Line, Tumor
Cell Survival drug effects
Delayed-Action Preparations
Drug Carriers pharmacology
Humans
Mechanical Phenomena
Polyesters pharmacology
Polymerization
Stereoisomerism
Antineoplastic Agents chemistry
Antioxidants chemistry
Drug Carriers chemistry
Lignin chemistry
Polyesters chemistry
Resveratrol chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 119
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 30098362
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2018.08.040