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Human CD8 T-cell activation in acute and chronic chikungunya infection.
- Source :
-
Immunology [Immunology] 2018 Dec; Vol. 155 (4), pp. 499-504. Date of Electronic Publication: 2018 Sep 03. - Publication Year :
- 2018
-
Abstract
- There is a need for more detailed elucidation of T-cell immunity in chikungunya infection. CD8 T cells are one of main actors against viruses. Here, we analysed CD8 <superscript>+</superscript> T lymphocytes from patients in the acute and chronic phases of chikungunya disease (CHIKD). Our results demonstrate that CD8 <superscript>+</superscript> T cells expressed higher ex vivo granzyme B, perforin and CD107A expression in patients in the acute phase of CHIKD compared with healthy individuals and higher ex vivo expression of CD69, interleukin-17A, interleukin-10 and CD95 ligand, and co-expression of CD95/CD95 ligand. These results elucidate the importance of these lymphocytes, demonstrating immune mechanisms mediated in human chikungunya infection.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Antigens, CD biosynthesis
Antigens, CD immunology
Antigens, Differentiation, T-Lymphocyte biosynthesis
Antigens, Differentiation, T-Lymphocyte immunology
Chikungunya Fever pathology
Chikungunya Fever virology
Cytokines immunology
Cytotoxicity, Immunologic immunology
Fas Ligand Protein biosynthesis
Fas Ligand Protein immunology
Granzymes biosynthesis
Granzymes immunology
Humans
Interleukin-10 biosynthesis
Interleukin-10 immunology
Interleukin-17 biosynthesis
Interleukin-17 immunology
Lectins, C-Type biosynthesis
Lectins, C-Type immunology
Lysosomal-Associated Membrane Protein 1 biosynthesis
Lysosomal-Associated Membrane Protein 1 immunology
Perforin biosynthesis
Perforin immunology
fas Receptor biosynthesis
fas Receptor immunology
CD8-Positive T-Lymphocytes immunology
Chikungunya Fever immunology
Chikungunya virus immunology
Cytokines biosynthesis
Lymphocyte Activation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2567
- Volume :
- 155
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30099739
- Full Text :
- https://doi.org/10.1111/imm.12992