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7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet.
- Source :
-
The British journal of nutrition [Br J Nutr] 2018 Oct; Vol. 120 (7), pp. 751-762. Date of Electronic Publication: 2018 Aug 14. - Publication Year :
- 2018
-
Abstract
- 7-Hydroxymatairesinol (7-HMR) is a plant lignan abundant in various concentrations in plant foods. The objective of this study was to test HMRLignan™, a purified form of 7-HMR, and the corresponding Picea abies extract (total extract P. abies; TEP) as dietary supplements on a background of a high-fat diet (HFD)-induced metabolic syndrome in mice and in the 3T3-L1 adipogenesis model. Mice, 3 weeks old, were fed a HFD for 60 d. Subgroups were treated with 3 mg/kg body weight 7-HMR (HMRLignan™) or 10 mg/kg body weight TEP by oral administration. 7-HMR and TEP limited the increase in body weight (-11 and -13 %) and fat mass (-11 and -18 %) in the HFD-fed mice. Epididymal adipocytes were 19 and -12 % smaller and the liver was less steatotic (-62 and -65 %). Serum lipids decreased in TEP-treated mice (-11 % cholesterol, -23 % LDL and -15 % TAG) and sugar metabolism was ameliorated by both lignan preparations, as shown by a more than 70 % decrease in insulin secretion and insulin resistance. The expression of several metabolic genes was modulated by the HFD with an effect that was reversed by lignan. In 3T3-L1 cells, the 7-HMR metabolites enterolactone (ENL) and enterodiol (END) showed a 40 % inhibition of cell differentiation accompanied by the inhibited expression of the adipogenic genes PPARγ, C/EBPα and aP2. Furthermore, END and ENL caused a 10 % reduction in TAG uptake in HEPA 1-6 hepatoma cells. In conclusion, 7-HMR and TEP reduce metabolic imbalances typical of the metabolic syndrome and obesity in male mice, whereas their metabolites inhibit adipogenesis and lipid uptake in vitro.
- Subjects :
- 3T3-L1 Cells
4-Butyrolactone analogs & derivatives
4-Butyrolactone pharmacology
4-Butyrolactone therapeutic use
Adipogenesis drug effects
Adipogenesis genetics
Adipose Tissue cytology
Adipose Tissue drug effects
Adipose Tissue metabolism
Animals
Anti-Obesity Agents pharmacology
Anti-Obesity Agents therapeutic use
Dietary Supplements
Fatty Liver drug therapy
Fatty Liver metabolism
Gene Expression
Insulin Resistance
Lignans therapeutic use
Lipids blood
Male
Metabolic Syndrome blood
Metabolic Syndrome etiology
Metabolic Syndrome metabolism
Mice
Mice, Inbred C57BL
Obesity blood
Obesity etiology
Obesity metabolism
Obesity prevention & control
Plant Extracts pharmacology
Plant Extracts therapeutic use
Blood Glucose metabolism
Body Weight drug effects
Diet, High-Fat
Lignans pharmacology
Lipid Metabolism drug effects
Metabolic Syndrome drug therapy
Picea chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 120
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 30105962
- Full Text :
- https://doi.org/10.1017/S0007114518001824