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[Clinical features and prognosis for anaplastic large cell lymphoma].
- Source :
-
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences [Zhong Nan Da Xue Xue Bao Yi Xue Ban] 2018 Jun 28; Vol. 43 (6), pp. 631-637. - Publication Year :
- 2018
-
Abstract
- Objective: To determine clinical and pathologic profiles for anaplastic large cell lymphoma (ALCL). Methods: The clinical data of 22 patients with ALCL were analyzed retrospectively. Therapentie effect of different treatment strategies on ALCL was evaluated. Results: The median age for these patients was 32(9-70) years old and the patients with positive ALK accounted for 68.2% (15/22). All patients underwent chemotherapy, including regiments of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), CHOPE (CHOP plus etoposide) or BEACOP (CHOP plus etoposide and bleomycin). Fourteen (63.6%) patients achieved initial complete remission (CR) and the CR rate for patients with ALK+ was significantly higher than that of patients with ALK- (P<0.05), while the age, gender, stage, beta 2-microglobulin (2-MG) level, lactate dehydrogenase (LDH) level, B symptoms had no significant effect on the rate of CR (P>0.05). After a median follow-up of 41 (2-150) months, 12 patients were overall survival, the median progression free time was 22.5 (2-150) months, and the age, gender, stage, IPI index, ALK expression level, beta 2-MG level, LDH level, and B symptoms had no significant effect on the rate of overall survival (P>0.05). Conclusion: ALK-positive occurs mainly in ALCL patients. The chemotherapy is still the main treatment, and CHOPE regimen is a better initial treatment scheme because the most patients show good prognosis.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Alkaline Phosphatase
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Bleomycin administration & dosage
Child
Cyclophosphamide administration & dosage
Doxorubicin administration & dosage
Etoposide administration & dosage
Female
Humans
Lymphoma, Large-Cell, Anaplastic enzymology
Lymphoma, Large-Cell, Anaplastic mortality
Male
Middle Aged
Prednisone administration & dosage
Prognosis
Retrospective Studies
Sex Factors
Treatment Outcome
Vincristine administration & dosage
Young Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Lymphoma, Large-Cell, Anaplastic drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1672-7347
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30110005
- Full Text :
- https://doi.org/10.11817/j.issn.1672-7347.2018.06.009